JAIST 北陸先端科学技術大学院大学 松村和明研究室

mark Original papers


93. Ohara Y, Nakai K, Ahmed S, Matsumura K, Ishihara K, Yusa S.I., pH-Responsive Polyion Complex Vesicle with Polyphosphobetaine Shells, Langmuir, in press.
92. Ahmed S, Matsumura K*, Hamada T*, Hydrophobic polyampholytes and non-freezing cold temperature stimulate internalization of Au nanoparticles to zwitterionic liposomes. Langmuir, in press.
91. Ahmed S, Okuma K, Matsumura K, Comparative analysis of the cellular entry of polystyrene and gold nanoparticles using the freeze concentration method. Biomater Sci, 6, 1791-1799 (2018).
90. Rajan R, Suzuki Y, Matsumura K, Zwitterionic Polymer Design that Inhibits Aggregation and Facilitates Insulin Refolding: Mechanistic Insights and Importance of Hydrophobicity. Macromol Biosci, 18, 1800016 (2018)
89. Sornkamnerd S, Okajima MK, Matsumura K, Kaneko T, Surface-Selective Control of Cell Orientation on Cyanobacterial Liquid Crystalline Gels. ACS Omega, 3, 6554-6559 (2018)
88. Ahmed S, Miyawaki O Matsumura K, Enhanced Adsorption of a Protein–Nanocarrier Complex onto Cell Membranes through a High Freeze Concentration by a Polyampholyte Cryoprotectant. Langmuir, 34, 2352-2362 (2018)


87. Rajan R, Matsumura K, Tuneable dual-thermoresponsive core–shell nanogels exhibiting UCST and LCST behavior. Macromol. Rapid Comm., 38, 1700478 (2017)
86. Takahashi M, Mohan P, Mukai K, Takeda Y, Matsumoto T, Matsumura K, Takakura M, Arai H, Taguchi T, Maenosno S, Magnetic Separation of Autophagosomes from Mammalian Cells using Multifunctional Hybrid Nanobeads. ACS Omega, 2, 4929-4937 (2017)
85. Ahmed S, Miyawaki O, Matsumura K, Role of cryoprotectants in freeze concentration technology for gene delivery process. Cryoiol Cryotechnol., 63, 147-154 (2017)
84. Ahmed S, Nakaji-Hirabayashi T, Watanabe T, Hohsaka T, Matsumura K. Freezing Assisted Gene Delivery Combined with Polyampholyte Nanocarriers. ACS Biomater. Sci. Eng., 3, 1677-1689 (2017)
83. Ahmed S, Fujita S, Matsumura K., A Freeze-Concentration and Polyampholyte-Modified Liposome-Based Antigen Delivery System for Effective Immunotherapy. Adv. Healthc. Mat. 6, 1700207 (2017)
82. Patel M., Kaneko T., Matsumura K., Switchable release nano-reservoirs for co-delivery of drugs via a facile micelle-hydrogel composite. J. Mater. Chem. B. 5, 3488-3497 (2017) (Selected as a Journal Front Cover)
81. Sakaguchi T, Nagano S, Hara M, Hyon S.H., Patel M, Matsumura K. Facile preparation of transparent poly(vinyl alcohol) hydrogels with uniform microcrystalline structure by hot pressing without using organic solvents. Polym J. 49, 535-542 (2017)
80. Kamoshita M, Kato T, Fujiwara K, Namiki T, Matsumura K, Hyon SH, Ito J, Kashiwazaki N., Vitrification with carboxylated ε-poly-L-lysine improves the in vitro and in vivo developmental ability of vitrified pronuclear-stage pig embryos. Plos One, 12, e0176711 (2017)
79. Rajan R, Matsumura K. Inhibition of protein aggregation by zwitterionic polymer-based core-shell nanogels. Sci. Rep., 7, 45777; doi: 10.1038/srep45777 (2017)
78. Das E, Matsumura K. Tunable phase‐separation behavior of thermoresponsive polyampholytes through molecular design. J. Polym. Sci. A. Polym. Chem. 55, 876-884 (2017)
77. Tsuji Y, Iwasaki T, Ogata H, Matsumoto Y, Kokeguchi S, Matsumura K, Hyon S-H, Shiotani M. The beneficial effect of carboxylated poly-L-lysine on cryosurvival of vitrified early stage embryos. Cryoletters, 38, 1-6 (2017)
76. Ota A, Matsumura K, Lee JJ, Sumi S, Hyon SH. StemCell KeepTM is effective for cryopreservation of human embryonic stem cells by vitrification. Cell Transplant, 26, 773-787 (2017)


75. Jain M, Matsumura K, Thixotropic injectable hydrogel using a polyampholyte and nanosilicate prepared directly after cryopreservation. Mater. Sci. Eng. C., 69, 1273-1281 (2016)
74. Dureamae I, Nishida M, Nakaji-Hirabayashi T, Matsumura K, Kitano H. Biodegradable shape memory polymers functionalized with anti-biofouling interpenetrating polymer networks. J Mater Chem B 4, 5394-5404 (2016)
73. Ahmed S, Fujita S, Matsumura K. Enhanced Protein Internalization and Efficient Endosomal Escape Using Polyampholyte-Modified Liposomes and Freeze Concentration. Nanoscale 8, 15888-15901 (2016) (Selected as a Journal Back Cover)
72. Ahmed S, Matsumura K. Novel Concentration-Based Freezing Method for Efficient Protein Delivery. Cryobiol. Cryotechnol. 62, 143-147 (2016)
71. Matsumura K, Kawamoto K, Takeuchi M, Yoshimura S, Tanaka D, Hyon SH. Cryopreservation of a Two-Dimensional Monolayer Using a Slow Vitrification Method with Polyampholyte to Inhibit Ice Crystal Formation. ACS Biomater Sci Eng, 2, 1023-1029, (2016)
70. Chimpibul W, Nagashima T, Hayashi F, Nakajima N, Hyon SH, Matsumura K. Dextran Oxidized by a Malaprade Reaction Shows Main Chain Scission Through a Maillard Reaction Triggered by Schiff Base Formation Between Aldehydes and Amines. J Polym Sci Part A. Polym Chem, 54, 2254-2260, (2016).
69. Rajan R, Hayashi F, Nagashima T, Matsumura K, Toward a Molecular Understanding of the Mechanism of Cryopreservation by Polyampholytes: Cell Membrane Interactions and Hydrophobicity. Biomacromolecules, 17, 1882-1893, (2016)
68. Jain M, Matsumura K, Polyampholyte- and nanosilicate-based soft bionanocomposites with tailorable mechanical and cell adhesion properties. J Biomed Mater Res A, 104A, 1379-1386, (2016).
67. 松村和明 新規凍結保護物質の合成とその応用 低温生物工学会誌、62, 11-15, (2016)


66. Uemura M, Ishiguro H, Matsumura K. Effect of Carboxylated Poly-L-lysine on Morphological Change of Adherent Neuron-like Cells after Extracellular-freezing and Thawing. Cryobiol Cryotechnol, 61, 125-129, (2015)
65. Rajan R, Matsumura K. A zwitterionic polymer as a novel inhibitor of protein aggregation. J Mater Chem B, 3, 5683-5689, (2015) (Selected as a Journal Cover)
64. Takahashi M, Mohan P, Nakade A, Higashimine K, Mott D, Hamada T, Matsumura K, Taguchi T, Maenosono S. Ag/FeCo/Ag Core/Shell/Shell Magnetic Nanoparticles with Plasmonic Imaging Capability. Langmuir, 31,2228-2236, (2015).


63. Rajan R, Matsumura K. Preparation of novel synthetic cryoprotectants. Cryobiol Cryotechnol, 60, 99-103, (2014).
62. Vorontsov DA, Sazaki G, Hyon SH, Matsumura K, Furukawa Y, Antifreeze Effect of Carboxylated ε-Poly-l-lysine on the Growth Kinetics of Ice Crystals, J Phys Chem B, 118, 10240-10249, (2014).
61. Matsumura K, Nakajima N, Sugai H, Hyon SH, Self-degradation of tissue adhesive based on oxidized dextran and poly-L-lysine, Carbohydr Polym, 113, 32-38, (2014).
60. Ahmed S, Hayashi F, Nagashima T, Matsumura K, Protein Cytoplasmic Delivery using Polyampholyte Nanoparticles and Freeze Concentration. Biomaterials, 36, 6508-6518, (2014).
59. Shibao Y, Fujiwara K, Kawasaki Y, Matsumura K, Hyon SH, Ito J, Kashiwazaki N. The effect of a novel cryoprotective agent, carboxylated ε-poly-l-lysine, on the developmental ability of re-vitrified mouse embryos at the pronuclear stage. Cryobiology, 68, 200-204, (2014).
58. Suvannasara O, Tateyama S, Miyasato A, Matsumura K, Shimoda T, Ito T, Yamagata Y, Fujita T, Takaya N, Kaneko T. Biobased polyimides from 4-Aminocinnamic acid photodimer. Macromolecules, 47, 1586-1593, (2014).
57. Hyon SH, Nakajima N, Sugai H, Matsumura K, Low cytotoxic tissue adhesive based on oxidized dextran and epsilonpoly-L-lysine, J Biomed Mater Res A, 102A, 2511-2520, (2014).
56. Matsumura K, Kim HH, Hyon SH, Hypothermicpreservation of Mouse Induced Pluripotent Stem Cells by Polyampholytes, Curr Nanosci, 10, 222-226, (2014).
55. Jain M, Rajan R, Hyon SH, Matsumura K, Hydrogelation of dextran-based polyampholytes with cryoprotective properties via click chemistry. Biomater Sci, 2, 308-317(2014) (selected as a Journal Cover)


54. Watanabe H, Kohaya N, Kamoshita M, Fujikawa K, Matsumura K, Hyon SH, Ito J, Kashiwazaki N. Efficient production of live offspring from mouse oocytes vitrified with a novel cryoprotective agent, carboxylated ε-poly-L-lysine. PLoS One 8 (12), e83613 (2013)
53. Matsumura K. Cryoprotective polyampholytes hydrogel. Cryobiol Cryotechnol 59, 111-115 (2013)
52. Maehara M, Sato M, Watanabe M, Matsunari H, Kokubo M, Kanai T, Sato M, Matsumura K, Hyon SH, Yokoyama M, Mochida J, Nagashima H. Development of a novel vitrification method for chondrocyte sheets. BMC Biotechnology, 2013, 13, 58.
51. Jin OS, Lee JH, Shin YC, Lee EJ, Lee JJ, Matsumura K, Hyon SH, Han DW. Cryoprotection of fibroblasts by carboxylated poly-L-lysine upon repeated freeze/thaw cycles. Cryoletters, 34, 396-403, 2013.
50. Rajan R, Jain M, Matsumura K. Cryoprotective properties of completely synthetic polyampholytes via reversible addition-fragmentation chain transfer (RAFT) polymerization and the effects of hydrophobicity. J. Biomater. Sci. Polym. Ed. 24, 1767-1780 (2013)
49. Matsumura K, Hayashi F, Nagashima T, Hyon SH. Cryoprotective properties of polyampholytes. Cryobiol Cryotechnol. 59, 23-28, (2013).
48. Matsumura K, Hayashi F, Nagashima T, Hyon SH. Long-term cryopreservation of human mesenchymal stem cells using carboxylated poly-L-lysine without the addition of proteins or dimethyl sulfoxide. J. Biomater. Sci. Polym. Ed. 24, 1484-1497, (2013).


47. Vrana N, Matsumura K, Hyon SH, Geever L, Kennedy J, Lyons J, Higginbotham C, Cahill P, McGuinness G: “Cell Encapsulation and Cryostorage in PVA/Gelatin Cryogels: Incorporation of Carboxylated ε-Poly -L-Lysine as Cryoprotectant” J Tissue Eng Regen Med 6, 280-290 (2012)
46. Kanamune J, Kina T, Iwanaga Y, Noguchi H, Matsumura K, Hyon SH. Attenuation of murine GVHD by a tea polyphenol. Cell Transplant 21, 909-918 (2012)


45. Matsumura K, Hayashi F, Nagashima T, Hyon SH. Evaluation of freezing behaviors of carboxylated polu-L-lysine possessing cryoprotective properties by solid-state-NMR. Cryobiology and Cryotechnology 57, 131-134 (2011)
44. Matsumura K, Bae JY, Kim HH, Hyon SH. Effective vitrification of human induced pluripotent stem cells using carboxylated ε-poly-L-lysine. Cryobiology, 63, 76-83 (2011).
43. Inui H, Mizuno J, Hyon SH, Matsumura K, Kikuchi E, Noguchi K, Tanji Y, Akaishi K, Anzai K, Maruyama Y. Development of a Low Toxicity and Completely Serum-Free Vitrification System Combining a Cryo-Nano-Hole Vitrification Container with Antifreeze Polyamino-acid (Carboxylated Poly-L-Lysine) for assisted reproductive technology (ART). J Reprod Engineer. 14, 19-28, 2011.
42. Nakamura J, Nakajima N, Matsumura K, Hyon SH: “In vivo cancer targeting of water-soluble taxol by folic acid immobilization” J Nanomedic Nanotechnol, 2 (1), 1000106, (2011)
41. Kobayashi M, Matsumura K, Hyon SH. “A preliminary in vivo study of artificial meniscus using the uniaxial oriented reinforced compressive polyvinyl alcohol-hydrogel ( PVA-H )” Trends in Biomate Art Organs 25(3), 107-111 (2011).
40. Kakuta Y, Okumi M, Isaka Y, Tsutahara K, Abe T, Yazawa K, Ichimaru N, Matsumura K, Hyon SH, Takahara S, Nonomura N. “Epigallocatechin-3-gallate protects kidneys from ischemia reperfusion injury by HO-1 upregulation and inhibition of macrophage infiltration” Transplantation International 24(5), 514-522 (2011)
39. Yanagi S, Matsumura K, Marui A, Morishima M, Hyon S-H, Ikeda T, Sakata R. “Oral pretreatment with an appropriate dose of a green tea polyphenol facilitates cardioprotection against ischemia-reperfusion injury in an isolated rat heart model” J Thorac Cardiov Sur 141; 511-517 (2011).


38. Matsumura K, Bae JY, Hyon SH. “Large scale vitrification for the preservation of human induced pluripotent stem (iPS) cells using carboxylated poly-L-lysine.” Low Temperature Medicine 36(3): 65-68 (2010).
37. Matsumura K, Bae JY, Hyon SH: “ Polyampholytes as cryoprotective agents for mammalian cell cryopreservation” Cell Transplant.19; 691-699 (2010).
36. Nakamura J, Nakajima N, Matsumura K, Hyon S-H. “Water-soluble taxol conjugates with dextran ant targets tumor cells by folic acid immobilization” Anticancer Res 30: 903-909 (2010).
35. Tanaka S, Hayashi T, Tateyama H, Matsumura K, Hyon SH, “Application of the bactericidal activity of epsilon-poly-L lysine to the storage of human platelet concentrates” Transfusion 50: 932-940 (2010).
34. Matsumura K, Hayami T, Hyon SH, Tsutsumi S, “Control of proliferation and differentiation of osteoblasts on apatite coated poly(vinyl alcohol) hydrogel as an artificial articular cartilage material.” J Biomed Mater Res.A 92A: 1225-1232 (2010)
33. Bae JY, Han DW, Matsumura K, Wakitani S, Nawata M, Hyon SH, “Nonfrozen Preservation of Articular Cartilage by Epigallocatechin-3-Gallate Reversibly Regulating Cell Cycle and NF-kappa B Expression” Tissue Eng A 16: 595-603 (2010)
32. Kashiwa K, Kotobuki N, Tadokoro M, Matsumura K, Hyon SH, Yoshiya S, Ohgushi H. “Effects of epigallocatechin-gallate (EGCG) on osteogenic capability of human mesenchymal stem cells (MSCs) after suspension in phosphate buffered saline” Tissue Eng A. 16: 91-100 (2010).


31. Matsumura K, Hyon SH: “Polyampholytes as low toxic efficient cryoprotective agents with antifreeze protein properties” Biomaterials 30: 4842-4849 (2009) .
30. Matsumura K, Takayama H, Bae JY, Kurihara M, Tsutsumi S, Hyon SH.: “Preservation of platelets by adding epigallocatechin-3-O-gallate to platelet concentrates.” Cell Transplant. 18: 521-528 (2009)
29. Bae JY, MatsumuraK, Wakitani S, Kawaguchi A, Tsutsumi S, Hyon SH.: “Beneficial storage effects of epigallocatechin-3-O-gallate on the articular cartilage of rabbit osteochondral allografts.” Cell Transplant 18: 505-512 (2009).
28. Kim HH, Kawazoe T, Matsumura K, Suzuki S, Hyon SH. : “Long-term preservation of rat skin tissue by epigallocatechin-3-O-gallate” Cell Transplant. 18: 513-519 (2009).
27. Bae JY, Kanamune J, Han DW, Matsumura K, Hyon SH.: Reversible regulation of cell cycle-related genes by epigallocatechin gallate for hibernation of neonatal human tarsal fibroblasts. Cell Transplant. 18: 459-469 (2009).


26. Kim HH, Kawazoe T, Han DW, Matsumura K, Suzuki S, Tsutsumi S, Hyon SH.: “Enhanced wound healing by epigallocatechin gallate-incorpolated collagen sponge in diabetic mice.” Wound Repair Regen 16, 714-720 (2008)
25. Matsumura K, Kaihatsu K, Mori S, Cho HH, Kato N, Hyon SH: “Enhanced antitumor activities of (-)-Epigallocatechin-3-O-gallate fatty acid monoester derivatives in vitro and in vivo.” Biochem Biophys Res Commun 377, 1118-1122 (2008).
24. Han DW, Matsumura K, Kim B, Hyon SH: “Time-dependent intracellular trafficking of FITC-conjugated epigallocatechin-3-O-gallate in L-929 cells.” Bioorg Med Chem 16. 9652-9659, (2008).
23. Cho HH, Han DW, Matsumura K, Tsutsumi S, Hyon SH.: ”The behavior of vascular smooth muscle cells and platelets onto epigallocatechin gallate-releasing poly(L-lactide-co-ε-caprolactone) as stent-coating materials.” Biomaterials 29. 884-893, (2008)


22. Matsumura K, Hyon SH, Nakajima N, Tsutsumi S. : ”Effects on gingival cells of hydroxyapatite immobilized on poly(ethylene-co-vinyl alcohol)” J Biomed Mater Res A 82A 288-295, (2007)
21. Kim JY, Kina T, Iwanaga Y, Noguchi H, Matsumura K, Hyon SH.: ”Tea polyphenol inhibits allostimulation in mixed lymphocyte culture” Cell Transplant 16(1), 75-83 (2007)
20. Hayami T, Matsumura K, Kusunoki M, Nishikawa H, Hontsu S. “Imparting cell adhesion to poly(vinyl alcohol) hydrogel by coating with hydroxyapatite thin film” Materials Letters. 61(13), 2667-2670 (2007)
19. Matsumura K, Kim JY, Tsutsumi S, Hyon SH. “Hibernation, reversible cell growth inhibition by epigallocatechin-3-O-gallate” Jounal of Biotechnology, 127(4), 758-764 (2007)
18. Cho HH, Matsumura K, Nakajima N, Han DW, Tsutsumi S, Hyon SH, “Degradation control of collagen by epigallocatechin-3-O-gallate” Key Engineering Mater, 342-343, 781-784, (2007)
17. Watazu A, Li Y, Tsutsumi S, Matsumura K, Saito N., “Selective bone formation on hydroxyapatite-granule-implanted titanium”, Key Engineering Mater, 330-332, 459-462 (2007)
16. Han DW, Cho HH, Jung DY, Lee JJ, Matsumura K, Park JC, Hyon SH, “Vascular smooth muscle cell behaviours onto epigallocatechin-3-O-gallate-blended L-lactide/ε-caprolactone copolymers” Key Engineering Mater, 342-343, 189-192 (2007)


15. Hyon SH, Matsumura K, Kim JY. : The Application of Green Tea Polyphenol to Regenerative Medicine. Biomaterials Research 10(3), 117-124 (2006)
14. Hyon SH, Kim DH, Cui W, Matsumura K, Kim JY, Tsutsumi S. : “Preservation of rat aortic tissue transplant with green tea polyphenols”. Cell Transplant. 15(10):881-883 (2006)
13. Matsumura K, Tsutsumi S, Hyon SH. “Epigallocatechin-3-O-gallate As a Novel Preservation Additive for Tooth Transplantation.” Journal of Oral Tissue Engineering 3(3):125-130.(2006)
12. Han DW, Cho HH, Matsumura K, Park JC, Hyon SH. “Attenuated proliferation and migration of rat aortic smooth muscle cells into epigallocatechin-3-O-gallate-loaded collagen matrices” Biomaterials Research 10(1): 36-42, (2006).


11. Matsumura K., Hyon S.-H., Nakajima N., Iwata H., Watazu A., Tsutsumi S. “Surface modification of poly(ethylene-co-vinyl alcohol)(EVA) : Hydroxyapatite immobilization and control of periodontal ligament cells differentiation.” Biomaterials 25:4817-4824(2004)
10. 松村和明、玄 丞烋、堤 定美, “人工歯根材料としてのエチレン-ビニルアルコール共重合体へのハイドロキシアパタイトの固定化” 再生歯科医学会誌 2(2):101-107, (2004)
09. 松村和明、玄 丞烋、堤 定美, “ハイドロキシアパタイト固定化エチレン-ビニルアルコール共重合体上での歯根膜細胞培養” 再生歯科医学会誌 2(2):116-123, (2004)
08. Ushio K., Oka M., Hyon S.-H., Hayami T., Yura S., Matsumura K., Toguchida J. Nakamura T., “Attachment of artificial cartilage to underlying bone” J. Biomed Mater Res Part B: Appl Biomater., 68B: 59-68, (2004)
07. Matsumura K., Hyon S.-H., Nakajima N., Peng C., Iwata H., Tsutsumi S. “Adhesion between polylethylene-co-vinyl alcohol (EVA) and titanium”, J. Biomed Mater. Res, 60(2): 309-315(2002)
06. Peng C., Tsutsumi S., Matsumura K., Nakajima N., Hyon S.-H. “Morphologic study and synthesis of type I collagen and fibronectin of human periodontal ligament cells cultured on poly(ethylene-co-vinyl alcohol) (EVA) with collagen immobilization” J. Biomed Mater. Res, 54: 241-246 (2001)
05. Park J.-C., Hwang Y.-S., Lee J.-E., Park K.-D., Matsumura K., Hyon S.-H., Suh H. “Type Ⅰatelocollagen grafting onto ozone-treated polyurethane films: Cell attachment, proliferation, and collagen synthesis” J. Biomed Mater. Res, 52: 669-677 (2000)
04. 彭 春岩, 堤 定美, 松村和明, 中島直喜, 玄 丞烋, “歯根膜を有する人工歯根の開発 第二報コラーゲン固定化エチレンービニルアルコール共重合体(EVA)へのヒト歯根膜由来細胞培養” 歯科材料・器械 19: 464-469 (2000)
03. 松村和明, 玄 丞烋, 中島直喜, 彭 春岩, 岩田博夫, 堤 定美”歯根膜を有する人工歯根の開発 第一報エチレンービニルアルコール共重合体のチタンへの接着と表面処理” 歯科材料・器械 19: 361-366 (2000)
02. Matsumura K., Hyon S.-H., Nakajima N. and Tsutsumi S. “Surface Modification of Poly(ethylene-vinyl alchohol) (EVA). Part Ⅰ. Introduction of Carboxyl Groups and Immobilization of Collagen” J. Biomed. Mater. Res., 50: 512-517(2000)
01. 松村和明, 玄 丞烋, 岡 正典, 牛尾一康, 堤 定美, “犬膝関節軟骨およびPVAハイドロゲル人工関節軟骨のSEMおよびAFM観察” 高分子論文集, 55: 786-790(1998)